• Users Online: 86
  • Print this page
  • Email this page
Year : 2021  |  Volume : 10  |  Issue : 3  |  Page : 352-354

Pneumocystis jirovecii pneumonia: A life-threatening infection of the immunocompromised

1 Department of Microbiology, Midnapore Medical College and Hospital, Midnapore, West Bengal, India
2 Department of Microbiology, Malda Medical College and Hospital, Malda, West Bengal, India

Correspondence Address:
Dr. Subhayan Das Gupta
Department of Microbiology, Malda Medical College, Uma Roy Sarani, Malda 732101, West Bengal
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijrc.ijrc_65_21

Rights and Permissions

Pneumocystis pneumonia (PCP) is a fatal pulmonary infection caused by an ascomycetous fungus, Pneumocystis jirovecii. The infection is mostly seen in patients with underlying disease conditions that alter the host immune status. However, immunocompetent hosts may also be transiently infected with self-limiting mild lower respiratory tract infection. Diagnosis of PCP requires demonstration of cysts of Pneumocystis in the lungs of the patient. Although an open lung biopsy is the most reliable method, a bronchoalveolar lavage is always more practical and nearly as sensitive. We report a case of a 32-year-old human immunodeficiency virus (HIV)-infected woman who presented with a 2-month history of nonproductive cough, respiratory distress, and fever. Her sputum examination showed growth of Klebsiella pneumonia and was sensitive only to levofloxacin. No acid-fast organisms were demonstrated. High-resolution computerized tomography scan of the thorax showed consolidated airspaces bilaterally with ground-glass opacities. Her CD4 count was 110 cells/mm3. PCP was diagnosed by performing a Giemsa stain of bronchoalveolar lavage, which revealed cysts of P. jirovecii. Diagnosis was further confirmed by the elevated serum (1-3)-β-D glucan levels. She was started on co-trimoxazole and prednisolone, following which her symptoms gradually improved. PCP is one of the most common causes of HIV-associated mortality and a rapid diagnosis with an early initiation of treatment can significantly improve patient outcomes.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded22    
    Comments [Add]    

Recommend this journal