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LETTER TO EDITOR
Year : 2022  |  Volume : 11  |  Issue : 1  |  Page : 86

Pleural fluid cholesterol, transudates, and exudates: Correspondence


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. D. Y. Patil University, Pune, Maharashtra, India

Date of Submission24-Nov-2021
Date of Acceptance24-Nov-2021
Date of Web Publication04-Jan-2022

Correspondence Address:
Dr. Pathum Sookaromdee
Private Academic Consultant, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijrc.ijrc_144_21

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How to cite this article:
Sookaromdee P, Wiwanitkit V. Pleural fluid cholesterol, transudates, and exudates: Correspondence. Indian J Respir Care 2022;11:86

How to cite this URL:
Sookaromdee P, Wiwanitkit V. Pleural fluid cholesterol, transudates, and exudates: Correspondence. Indian J Respir Care [serial online] 2022 [cited 2022 Jan 29];11:86. Available from: http://www.ijrc.in/text.asp?2022/11/1/86/334819



Sir,

We would like to share ideas on “Pleural fluid cholesterol: A promising marker to differentiate transudates and exudates.”[1] Rustogi et al. concluded that “ pfCHOL is a less complex, cost-effective, reliable diagnostic marker and is as good as the Light's criteria to differentiate transudates and exudates.[1] We agree that pfCHOL might be helpful for the diagnosis of effusion. The observation in the present work repeatedly confirms the concept in the previous publication.[2] There are some laboratory medicine concerns. First, the technique for analyzing cholesterol in pleural fluid is still nonstandard. Applying CHOD-PAP method, which is used for serum sample analysis, might be possible, but there must be a standard evaluation of technique (diagnostic sensitivity, interference, reference value, etc.). Effusion cholesterol level is also affected by serum level, which is related to intake. Hence, a measurement of ratio compared to serum is needed.[3]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Rustogi N, Gupta H. Pleural fluid cholesterol: A promising marker to differentiate transudates and exudates. Indian J Respir Care 2021;10:326-9.  Back to cited text no. 1
  [Full text]  
2.
Hamal AB, Yogi KN, Bam N, Das SK, Karn R. Pleural fluid cholesterol in differentiating exudative and transudative pleural effusion. Pulm Med 2013;2013:135036.  Back to cited text no. 2
    
3.
Shen Y, Zhu H, Wan C, Chen L, Wang T, Yang T, et al. Can cholesterol be used to distinguish pleural exudates from transudates? Evidence from a bivariate meta-analysis. BMC Pulm Med 2014;14:61.  Back to cited text no. 3
    




 

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