|LETTER TO EDITOR
|Year : 2022 | Volume
| Issue : 1 | Page : 86
Pleural fluid cholesterol, transudates, and exudates: Correspondence
Pathum Sookaromdee1, Viroj Wiwanitkit2
1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. D. Y. Patil University, Pune, Maharashtra, India
|Date of Submission||24-Nov-2021|
|Date of Acceptance||24-Nov-2021|
|Date of Web Publication||04-Jan-2022|
Dr. Pathum Sookaromdee
Private Academic Consultant, Bangkok
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Sookaromdee P, Wiwanitkit V. Pleural fluid cholesterol, transudates, and exudates: Correspondence. Indian J Respir Care 2022;11:86
|How to cite this URL:|
Sookaromdee P, Wiwanitkit V. Pleural fluid cholesterol, transudates, and exudates: Correspondence. Indian J Respir Care [serial online] 2022 [cited 2022 Jan 29];11:86. Available from: http://www.ijrc.in/text.asp?2022/11/1/86/334819
We would like to share ideas on “Pleural fluid cholesterol: A promising marker to differentiate transudates and exudates.” Rustogi et al. concluded that “ pfCHOL is a less complex, cost-effective, reliable diagnostic marker and is as good as the Light's criteria to differentiate transudates and exudates.” We agree that pfCHOL might be helpful for the diagnosis of effusion. The observation in the present work repeatedly confirms the concept in the previous publication. There are some laboratory medicine concerns. First, the technique for analyzing cholesterol in pleural fluid is still nonstandard. Applying CHOD-PAP method, which is used for serum sample analysis, might be possible, but there must be a standard evaluation of technique (diagnostic sensitivity, interference, reference value, etc.). Effusion cholesterol level is also affected by serum level, which is related to intake. Hence, a measurement of ratio compared to serum is needed.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Rustogi N, Gupta H. Pleural fluid cholesterol: A promising marker to differentiate transudates and exudates. Indian J Respir Care 2021;10:326-9. [Full text]
Hamal AB, Yogi KN, Bam N, Das SK, Karn R. Pleural fluid cholesterol in differentiating exudative and transudative pleural effusion. Pulm Med 2013;2013:135036.
Shen Y, Zhu H, Wan C, Chen L, Wang T, Yang T, et al.
Can cholesterol be used to distinguish pleural exudates from transudates? Evidence from a bivariate meta-analysis. BMC Pulm Med 2014;14:61.