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 Table of Contents  
LETTER TO EDITOR
Year : 2022  |  Volume : 11  |  Issue : 2  |  Page : 193

Cartridge-Based nucleic acid amplification test for the diagnosis of pulmonary tuberculosis: correspondence


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. D. Y. Patil University, Pune, Maharashtra, India

Date of Submission06-Jan-2022
Date of Decision11-Feb-2022
Date of Acceptance12-Feb-2022
Date of Web Publication08-Apr-2022

Correspondence Address:
Dr. Rujittika Mungmunpuntipantip
Private Academic Consultant, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijrc.ijrc_6_22

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Cartridge-Based nucleic acid amplification test for the diagnosis of pulmonary tuberculosis: correspondence. Indian J Respir Care 2022;11:193

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Cartridge-Based nucleic acid amplification test for the diagnosis of pulmonary tuberculosis: correspondence. Indian J Respir Care [serial online] 2022 [cited 2022 Jun 29];11:193. Available from: http://www.ijrc.in/text.asp?2022/11/2/193/342777



Dear Editor,

We would like to share ideas on the publication, “A comparative study of cartridge-based nucleic acid amplification test and Ziehl–Neelsen stain with culture on Lowenstein–Jensen media as the gold standard for the diagnosis of pulmonary tuberculosis.”[1] Roy et al. concluded that “whereas culture remains the gold standard for the diagnosis of tuberculosis (TB), CBNAAT has taken over the domain of diagnosis owing to its high sensitivity and rapid turnover time.”[1] We agree that the new alternative technique might be useful for diagnosing TB. Previous reports also showed that the new technique might be superior for diagnosis.[2],[3],[4] However, there are some issues for further studies. First, the cost-effectiveness of the new alternative technique should be assessed similar to [Table 1]. For a setting with limited resources, cost-effectiveness is an important issue. Second, the new system might be based on a more complex tool. It might require a medical technologist for quality control of analysis. It is questionable whether classical staining is still more functional in rural fieldwork. Finally, it should note that the new technique has a specificity of about 90% compared to culture.[3] Hence, there is still a chance of nondiagnosis, which might lead to difficulty in disease control.
Table 1: Cost-effectiveness analysis comparing between intradermal and intramuscular COVID-19 vaccine administration

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Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Roy RD, Gupta SD. A comparative study of cartridge-based nucleic acid amplification test and Ziehl-Neelsen stain with culture on Lowenstein-Jensen media as gold standard for the diagnosis of pulmonary tuberculosis. Indian J Respir Care 2022;11:39-42.  Back to cited text no. 1
  [Full text]  
2.
Chandrappa N, Rastogi A, Bhatnagar AK. Cartridge based nucleic acid amplification test is superior in diagnosing lymphnode tuberculosis. Indian J Tuberc 2019;66:402-6.  Back to cited text no. 2
    
3.
Dayal R, Yadav A, Agarwal D, Kumar M, Kamal R, Singh D, et al. Comparison of diagnostic yield of tuberculosis loop-mediated isothermal amplification assay with cartridge-based nucleic acid amplification test, acid-fast bacilli microscopy, and mycobacteria growth indicator tube culture in children with pulmonary tuberculosis. J Pediatric Infect Dis Soc 2021;10:83-7.  Back to cited text no. 3
    
4.
Youngs J, Patil S, Jain Y. A prospective study evaluating the impact of cartridge-based nucleic acid amplification test (CBNAAT) on the management of tuberculosis in a low-resource high-burden Indian rural setting. J Family Med Prim Care 2018;7:982-92.  Back to cited text no. 4
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